The first records of the pharmacy date back to the year 1672. The spice merchant Andrea De Auria was owner of an "Apotheca ad usum semplicitariae" in Corso Umberto where now stands the Palazzo Baldinotti.

In 1697 Marta Lambruzzi, the widow of Andrea De Auria, sells the "Apotheca" to Francesco Ippolito Prandoni, after having the value of medicinals and furnishings valued at 747 scudi and 97 baiocchi by two independent appraisers.

Francesco Ippolito Prandoni in turn sells the Apotheca to the spice merchant Luigi Ramacogi.

Upon Ramacogi's death, his widow Camilla Pierantoni, sells the "Apotheca ad usum Pharmacopeae" to the spice merchant Giuseppe Meli. To complete the transaction, an inventory is compiled by the Noble Roman College of Chemistry and Pharmeceutics and values the pharmacy's stock at 807 scudi and 46 baiocchi.

Giuseppe Meli in 1795 moves the drug store from Corso Umberto to it's current location in Via del Gambero where it is managed by his family for 74 years. In 1871 Paolina Silvestri Meli sells the drug store to Dr. Domenico Garmeri for 35,000 lire. When Rome is declared the capital of Italy in 1870, the pharmacy becomes supplier to His Majesty the King of Italy, the Queen Mother and His Royal Highness the Duke of Aosta.

In 1887 the pharmacy is sold to Dr. Enrico Cherubini for the price of lire 42,000, who keeps it until 1924 when he in turn sells it to Dr. Alberto Merenda.

In 1948 Dr. Franco Sbarigia acquires from the heirs of Alberto Merenda the pharmacy for lire 22,000,000. Dr Sbrigia recovered and restored with great dedication the first inventory of 1697, in which all property transactions and prices are recorded. These stand as witnesses to the cultural and professional wealth that the pharmacy contributed in the fields of therapy and pharmaceutics.

Today his grandson Dr. Giulio Tassoni,and his daughter Dr Emanuela continue to maintain the pharmacy operational with professionality and dedication.